Substrate: Retinoic acid receptor alpha (Nuclear hormone receptor family)
Seq-ID: P10276 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-24895   RXRA_HUMAN
MINT-25022   RXRA_MOUSE
MINT-2834436   NCOA3_HUMAN
MINT-2862542   UBE3A_HUMAN
MINT-5209864   NCOA1_HUMAN
MINT-5209905   MED1_HUMAN
MINT-7972514   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
retinoic acid binding,
retinoic acid receptor activity,
chromatin DNA binding,
protein domain specific binding,
transcription corepressor activity,
enzyme binding,
retinoic acid-responsive element binding,
transcription coactivator activity,
zinc ion binding,
receptor binding,
sequence-specific DNA binding transcription factor activity,
steroid hormone receptor activity		 cytoplasm,
cell surface,
nucleus		 negative regulation of granulocyte differentiation,
negative regulation of tumor necrosis factor production,
positive regulation of cell cycle,
response to estradiol stimulus,
positive regulation of gene-specific transcription,
positive regulation of interleukin-5 production,
positive regulation of binding,
cellular response to estrogen stimulus,
estrogen receptor signaling pathway,
cellular response to retinoic acid,
negative regulation of interferon-gamma production,
positive regulation of transcription from RNA polymerase II promoter,
apoptotic cell clearance,
positive regulation of interleukin-13 production,
negative regulation of gene-specific transcription,
positive regulation of interleukin-4 production,
positive regulation of cell proliferation,
protein amino acid phosphorylation,
transcription,
positive regulation of T-helper 2 cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 77 SSEEIVPSPPSPPPLPRIYKP CDK7 9230306
LTP
0.97
 - -
0.48
 --
T 181 KPECSESYTLTPEVGELIEKV - 15657432
LTP
0.22
 - -
0.27
 --
S 445 GGLAPPPGSCSPSLSPSSNRS - 15657432
LTP
0.31
 - -
0.90
 --
S 461 SSNRSSPATHSP          - 15657432
LTP
0.21
 - -
0.68
 --

Substrate: Retinoic acid receptor alpha (Nuclear hormone receptor family)
Seq-ID: P11416 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
retinoic acid receptor activity,
zinc ion binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein binding,
steroid hormone receptor activity		 neuronal cell body,
dendrite,
nucleus		 negative regulation of cartilage development,
positive regulation of cell proliferation,
transcription,
ureteric bud development,
negative regulation of cell differentiation,
regulation of granulocyte differentiation,
spermatogenesis,
chondroblast differentiation,
ventricular cardiac muscle cell differentiation,
cellular response to lipopolysaccharide,
response to retinoic acid,
positive regulation of transcription from RNA polymerase II promoter,
negative regulation of transcription from RNA polymerase II promoter,
negative regulation of translational initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 369 LKVYVRKRRPSRPHMFPKMLM PKA_alpha 7476969
LTP
0.24
 MOD_PKA_1
 - HOLI
0.40
 1DKF 81.15%

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